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Vilela et al., 2020), and boosting the expression of neurogenesis-related and proliferative genes in aged animals (Buckley et al., 2023)

Reducing the dose and increasing water intake can often help

Helling G, Wahlin S, Smedberg M, Pettersson L, Tjder I, Norberg , Rooyackers O, Wernerman J: Plasma glutamine concentrations in liver failure

A single-masked study involving 120 HF patients reported significant improvements in NYHA class, BNP, LVEF, and metabolic biomarkers after SMI administration, with superior effects compared to trimetazidine, suggesting a synergistic advantage of multitarget interventions (Wang et al., 2020b)

10.1016/0006-2952(95)00019-v 8