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53,54 In a 10-year prospective study by Criqui et al, 10 PAD patients with and without a history of cardiovascular disease had a significantly increased risk of dying of any cause or as a result of cardiovascular disease or CAD than age-matched controls

Carnitine Carnitine (3-hydroxy-4-trimethylamino-butyric acid or -hydroxy-gamma- N -trimethylamino-butyrate) thus appears essential to ensure proper metabolism of VPA