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PMID: 35729801 J Med ChemStructural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6 H-pyrimido[5,4- b][1,4]oxazin-7(8 H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants

The N -selenoethyl arm of the target amino acid, Se -protected with a PMB group, was inserted by reductive amination reaction 50

Mohammed, Y.A

The transition from animal studies to human populations is often complicated by differences in biological systems, making it difficult to directly translate animal-based results into practical human therapies

doi: 10.3389/fimmu.2019.03094 Received 27 September 2019 Accepted 18 December 2019 Published 10 January 2020 Volume 10 - 2019 Edited by Allen Jay Rosenspire, Wayne State University, United States Reviewed by agla Tkel, Temple University, United States