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Safety and efficacy of intravenous ultra-high dose methylcobalamin treatment for peripheral neuropathy: a phase i/ii open label clinical trial

20,21 High dose vitamin B6 and B12 supplement has been reported to trigger rosacea fulminans or pyoderma faciale, 22 clinically similar to rosacea but is mostly regarded as a separate entity

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Another mechanism that was suggested is the alteration of metformin on intestinal motility, thereby reducing the absorption of vitamin B 12 [87]

Other than that, the main causes behind this type of anemia are thalassemia, lead poisoning, and anemia caused by chronic diseases