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However, various physicochemical and biological factors within the IVD microenvironment, such as pH, osmotic pressure, hypoxia, inflammation, and mechanical stress, severely compromise the survival and function of transplanted cells

The antioxidant defense network, composed of antioxidants such as polyphenols, ascorbic acid, vitamin A, -lipoic acid, thioredoxin (Trx), glutathione (GSH), melatonin, coenzyme Q, -carotene, and -tocopherol, along with antioxidant enzymes including catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), and glutathione reductase (GR) ( 3 Core pathological mechanisms of ROS-mediated skin diseases Reactive oxygen species play complex and critical roles in the occurrence and development of skin diseases (Figure 2), with pathological mechanisms involving multiple levels, including abnormal cell signaling pathways, regulation of inflammatory responses, and direct oxidative damage

10.1038/sj.cdd.4401706 145 JiangH.TianS

Epub 2008 Dec 18