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It has been studied internationally in areas including infection, immune dysfunction, cancer support, and critical illness

Although trends toward greater symptomatic and MRI improvement were observed in younger patients and those with lower BMI, these analyses were exploratory and underpowered, particularly in the BMI 28 kg/m 2 subgroup

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However, certain groups may be at greater risk for this problem, including: Vegetarians Vegans Older adults People with digestive problems Signs of a B12 deficiency include fatigue, anemia, muscle weakness, nerve problems, mood disturbance, and intestinal problems

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