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Furthermore, PIT using the T-cell epitope of AK encapsulated with the TLR9 agonist CpG-ODN in nanoparticles, demonstrated significant attenuation of Th2-mediated allergic responses, reducing anaphylactic symptoms and Th2 cytokines while enhancing Th1 cytokine expression in a shrimp allergy model [162]

Additionally, vitamin D influences circadian rhythms by modulating the serotonin-melatonin conversion axis and exerts potential protective effects through interactions with sex hormones (92)

The Therapeutic Use Exemption (TUE) Program It should be noted that athletes who have a legitimate medical reason for using a prohibited substance or method that is on the List may apply for a TUE

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These are a family of enzymes which participate in cell detoxification