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Cancer Manag Res 11:91339143 Qadir MI et al (2020) RNA therapeutics: identification of novel targets leading to drug discovery

In 2020, there were an estimated 495,773 new cases and 466,003 deaths globally, ranking it 12th in incidence and 7th in cancer-related mortality [35]

This pathological process is implicated in the development of life-threatening conditions such as fulminant myocarditis (FM), acute respiratory distress syndrome (ARDS), primary or secondary hemophagocytic lymphohistiocytosis (HLH), cytokine release syndrome (CRS) associated with chimeric antigen receptor-modified T (CAR-T) therapy, and grade III to IV acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation

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According to the experimental design described in Section 2.2, the cells were then subjected to the respective treatments