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siRNA gene knockdown Cells were reverse-transfected with an ON-TARGET Plus siRNA SMARTPool targeting human RRM1 (targeting NM_001033.5, NM_001318064.1, NM_001318065.1, NM_001330193.1, Cat

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What they did: A two-phase study, first in a dish with human endothelial cells (HUVECs), then in a live rat with an ischemic limb (= they closed off the artery so that no blood reached the leg)

aeruginosa -secreted 15-lipoxygenase (pLoxA) mediates host arachidonic acidphosphatidylethanolamine (AAPE) oxidation for lipid peroxidation and degradation of the glutathione peroxidase 4 (GPX4) anti-ferroptosis system to induce ferroptosis 20,21,22