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Interestingly, the primary anti-ferroptotic function of LDHB is associated with the anti-ferroptotic function of CoQH2 and thus acts in parallel with the mitochondrial enzyme DHODH and also with the GPX4-dependent defense mechanism

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Downregulation of EZH2 and inhibition of deacetylases restored gene expression without altering promoter DNA methylation

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It is not strictly necessary both have reasonably long half-lives and the synthesis pathway is not a timed reaction requiring simultaneous arrival

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10.1074/jbc.RA119.008762 227 SchmidtS

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Antimicrob Agents Chemother (1999) 43(2):3604

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