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Muscle damage especially during eccentric exercise (active force generating lengthening contractions) is caused by immediate cellular and structural injury and subsequent biochemical responses during tissue repair [70,71]

Published 2022 May 5

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INTRODUCTION Most intracellular compartments, such as the cytosol, plastids and mitochondria constitute a reducing environment for protein cysteinyl groups, as they contain glutathione (GSH) in the mM range, as well as a glutathione reductase that keeps this pool reduced, transferring electrons from NADPH (Marty et al ., 2009, 2019)

MOTS-c is associated with mitochondrial signaling, which is why it is sometimes framed as an exercise-mimicking peptide