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The commentary was in response to a research paper in the journal that reported results of a study involving patients and others who smoke in emergency departments in the United Kingdom who were offered e-cigarettes as part of a smoking-cessation program

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In 2001 the US Institute of Medicine issued the report Clearing the Smoke, in which it was proposed that For many diseases attributable to tobacco use, reducing risk of disease by reducing exposure to tobacco toxicants is feasible 14,15

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