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In practice, clinicians commonly begin with 0.5 g - 2 g (10 - 40 mL of 50 mg/mL solution) administered as a slow IV push or diluted infusion, adjusting per response

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B12 is an essential nutrient, and its deficiency is common, especially among individuals following restricted diets like vegetarianism or veganism, pregnant or breastfeeding women, older adults, those who have undergone gastrointestinal surgery or have gastrointestinal disorders, and people with an autoimmune condition known as pernicious anaemia