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Ferroptosis inducers can potentiate immunotherapy by triggering immunogenic cell death, releasing tumor antigen and activating antitumor immune responses

Hasan T, Arora R, Bansal AK, Bhattacharya R, Sharma GS, Singh LR

The in vitro studies demonstrated that we designed liposome complex could penetrate faster and more specifically into AML cells, and trigger more efficiently the ROS elevation and GSH depletion thus result in AML cell apoptosis

In a rat model of hepatic ischemia reperfusion injury whereby cellular damage is caused by the restoration of oxygen delivery to a hypoxic liver pre-treatment with sulforaphane limited the reduction in glutathione (GSH) and the antioxidant enzymes, superoxide dismutase (SOD) and GSH peroxidase (GPx)

1g), as well as comparable representation of cells derived from independent technical and biological replicates across cell types with minimal batch effects (Fig