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Physical examination classically reveals an early diastolic tumor plop , though patients may also develop an S3 and S4 due to secondary heart failure or altered ventricular compliance from chronic mitral valve dysfunction

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Challenges and controversies The nutritional strategies demonstrate optimal potential when implemented as a complementary intervention alongside other treatment modalities

Dietary polyphenols can modulate the intestinal inflammatory response Nutr Rev

2.12 Statistical analysis Data are presented as mean SD