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We should note that while we did not specifically quantify the MS lesions in these patients, clinical evaluation revealed no new lesions on any patient during the study and no obvious change in lesion volume

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Liu G, Sun X, Bian J, Wu R, Guan X, Ouyang B

Through a division of labor, these domains cooperatively construct a conformationally mature :2 hemicomplex that is competent for subsequent steps in AP2 assembly