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cGAS can promote the perception of extracellular cyclic dinucleotides, making extracellular cyclic dinucleotides enter cells through endocytosis

Science 337: 790792 Mitchell DJ, Kim DT, Steinman L, Fathman CG, Rothbard JB (2000) Polyarginine enters cells more efficiently than other polycationic homopolymers

F.van BlitterswijkM.HardimanO.RavitsJ.et al (2025)

Although the body produces its own glutathione, levels can be depleted by UV light, poor diet, pollution, stress and aging

Also, the Mediterranean diet can be used by gut flora to make essential metabolites such as SCFAs, these metabolites improve ENS function, thereby enhancing gastrointestinal motility (143)