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Every vial is sealed under sterile conditions to prevent any contamination before it even leaves our facility

Targeting ATP7B-mediated copper efflux and sEV secretion thus represents a promising approach to restore cuproptosis sensitivity and overcome chemoresistance in refractory OSCC

This superficial location makes them vulnerable to repetitive strain but also makes them accessible for local treatment approaches

Aydin 1 , Jana Rieger 1 , Dimitrios Rallios 1,2 , Satoru Tanioka 1 , Charles Majoie 3 , Wim Van Zwam 4 , Aad van der Lugt 5 , Adam Hilbert 1 , Dietmar Frey 1,2 1 CLAIM - Charit Lab for Artificial Intelligence in Medicine, Charit Universittsmedizin Berlin, Germany, Berlin, Germany, 2 Department of Neurosurgery, Charit Universittsmedizin Berlin, Berlin, Germany, 3 Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 4 Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, 5 Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands Background and Aims: Characterizing Circle of Willis anatomical variations and pathologies is critical for stroke treatment planning and prognosis