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GPX4 inhibition effectively sensitizes resistant cancer cells to ferroptosis, particularly in malignancies such as clear-cell carcinomas, where oxidative stress is a critical vulnerability [16]

This distinguishes correct from incorrect peptide IDs in a manner analogous to the widely used Percolator algorithm 53 , though employing a distinct machine learning algorithm

In turn, phosphorylation of STAT1 leads to its translocation to the nucleus where it binds to the consensus gamma-activated sequence (GAS) sites in the promoters of several target genes and activates their expression (196)