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Ethics statement The animal study was reviewed and approved by Naval Medical University Animal Welfare and Ethics Committee

Front Immunol (2021) 12:661241

10.1021/acs.analchem.2c05774 9 BashiardesS.ChristodoulouC

The weight of these pre-clinical data, together with congruent findings in large animals and early human studies, underpins growing optimism that cellular regeneration can close the gap left by cryopreservation, GnRHa co-therapy and hormone replacement, all of which safeguard parenthood options but do little to repair endogenous ovarian function [169]