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Results Chronic ethanol exposure induced earlier and severer cognitive behavioral impairments in APP/PS1 mice To investigate the role of chronic ethanol exposure on cognitive behaviors of wild-type (WT) mice and APP/PS1 mice, continuously increasing ethanol exposure was conducted at three timepoints: 4-week, 8-week, 10-week, and four drinking paradigms: drinking in the dark (DID), two bottle choice (2BC), chronic intermittent ethanol (CIE), and intraperitoneal injection (IP) (Fig