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Manufacturers must comply with relevant regulations to ensure that the products are not used for human treatment

Epidermal PIH may resolve better and faster than dermal PIH where melanin accumulates in long-lived melanophages [27]. Melasma is also a chronic acquired hypermelanosis which involves increased melanin levels in the epidermis and/or dermis [28,29,30]. It manifests as bilateral dark or grayish-brown macules, more particularly located on the face

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Meanwhile, MR can also downregulate genes involved in an inflammatory response and immune cell infiltration, such as chemokine receptor (CCRs), chemokine ligand 7 (CCL7), IL-1, IL-6, IFN-, and TNF-