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SARS viruses are linked with hypothalamus and pituitary gland alterations

This peculiar type of lamellar fibrosis frequently contains entrapped melanocytic nests displaying mild cytological atypia, with either horizontal or irregular arrangement of the collagen bundles

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Additionally, IL-1, through its ability to activate signaling pathways such as MAPK upon binding to cellular receptors, can trigger the release of other cytokines and drive the polarization of Th17 cells

Mol Gen Genet 252: 503509