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Unfortunately, the benefit of androgen ablation is only transitory

Recent research has shown the potential role of mitochondrial DNA (mtDNA) mutations and mitochondrial dysfunctions in the development of connective tissue disorders [18,19,20]

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Although most of these data were generated in regenerative settings rather than during steady-state aging, they support a model in which aging can reduce the MuSC pool through probabilistic loss or dysfunction of MuSCs (or labeled lineages) without implying deterministic, subset-specific collapse of heterogeneity (Fig