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Although generally well-tolerated at low to moderate doses, high-dose curcumin can induce gastrointestinal discomfort, interfere with iron absorption, a concern in CKD-related anemia, and interact with drug-metabolizing enzymes [34,68]

This approach has the advantages of expanding the druggable target space, demonstrating polypharmacology (targeting multiple targets), and identifying therapeutic agents with relatively low molecular weights

It also regulates body composition, body fluids, muscle and bone growth, and possibly heart function

Mirocha, H.J

2 Elevated ROS levels result in overactivation of key signaling pathways such as extracellular-regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinase (MAPK), and phosphatidyl inositol 3 kinases (PI3Ks), which are crucial for regulating cell survival and propagation