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J Acad Nutr Diet 112:344

Digestive disorders Conditions affecting the gastrointestinal system - such as inflammatory bowel disease (IBD), Crohn's disease, celiac disease, and autoimmune gastritis - can cause inflammation in the intestinal walls, damaging cells and impairing B12 absorption

In the present study, high level of PGC-1 induced the expression of genes involved in lipid metabolism and detoxification, but failed to promote the expression of Nrf2 regulated genes involved in glutathione synthesis