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Curiously, despite the fact that X-ray crystallography requires rigid, crystalized samples and portrays the proteins as aperiodic crystals, this technique provided some early hints of intrinsic disorder that came from the missing residues in X-ray structures

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[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Halmos E.P., Christophersen C.T., Bird A.R., Shepherd S.J., Muir J.G., Gibson P.R