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All authors contributed significantly to this work and have approved the final manuscript

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Collectively, Se/LDH@PEG-M inhibits M1 macrophage polarization and promotes M2 phenotype through suppression of inflammatory pathways and enhancement of mitochondrial respiratory chain activity and ATP synthesis, thereby driving metabolic reprogramming from glycolysis to OXPHOS

Methionine synthases catalyze the final reaction in the methionine biosynthesis pathway, i.e., the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine, thus generating tetrahydrofolate and methionine

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