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Nevertheless, the protein levels of TNF and IL6 produced and secreted during the culture were significantly up-regulated (2-fold and 14-fold, respectively) in GFIPO medium

Jabs R, Seifert G, Steinhauser C

Adverse Reactions Reported with at Least a 5% Greater Incidence in Patients Treated with IMLYGIC Compared to GMCSF in the Clinical Study 1 Other adverse reactions associated with IMLYGIC in the open-label, randomized study include glomerulonephritis, vitiligo, cellulitis, and oral herpes