nrf2 glutathione peroxidase plays a critical role in mitigating lipid peroxidation and ferroptosis Molecular pathways of protection against

Altogether, these results demonstrate that ALS-causative mutations in FUS/TLS acquire partial to nearly complete loss of normal function in regulating splicing

Mitochondrial bioenergetics is closely associated with lipid metabolism, and lipid accumulation and metabolic dysregulation in podocytes lead to mitochondrial dysfunction, which results in podocyte injury

Cell cycle inhibitors disrupt tumor proliferation, while antibody therapies enhance tumor specificity

Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor gamma coactivator 1alpha

During osteoclastogenesis, RANKL-induced ROS induced PGC-1 via activation of CREB, and PGC-1 increased the production of reactive oxygen species and mitochondrial biogenesis, leading to the induction of osteoclastogenesis through a positive feedback mechanism [11, 12, 44, 45]