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(2021) Annu Rev Biochem 90, 535-558

In addition to serving as a substrate for cholesterol accumulation, oxLDL exerts a wide range of bioactivities that are consistent with it being critical for driving atherogenesis (Table 1)

In normal circumstances, only a small number of inflammatory factors such as TNF-, IL-1, and IL-6, from the systemic circulation may pass through the BBB to enter the brain (Tauber et al., 2017)

Stripped of any IGF-1 triggers, it lets scientists study how cells break down stored lipids and channel energy, all in tightly controlled adipocyte and metabolic assays

Currently, numerous methods and drugs are under investigation to modify, modulate, or mimic ECM components in order to effectively treat associated diseases