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While carnitine supplementation could have benefits, some recent studies suggest that chronic oral L-carnitine administration may be associated with an increased risk for atherosclerosis via increased trimethylamine (TMA) and/or trimethylamine N-Oxide (TMAO) levels (54, 55)

The effect of the CPT system on different tissues or organs is complex: the deficiency or over-activation of CPT disrupts the immune homeostasis by causing energy metabolism disorder and inflammatory oxidative damage and therefore contributes to the development of various acute and chronic inflammatory disorders and cancer

Emerging clinical evidence suggests that the SARS-CoV-2 virus can directly hijack or damage mitochondrial networks during acute infection, leaving a legacy of profound metabolic dysfunction long after the initial virus has been cleared

Mechanisms underlying the anti-wasting effect of L-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies

The immunosuppressive properties of carnitine also help eliminate intestinal inflammation [235]