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One nuance worth knowing: increased polyamine flux was actually framed as part of the benefit in the original obesity work, because cycling polyamines through synthesis and breakdown burns energy

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Most native proteins have marginally stable folding patterns, and the accumulation of misfolded proteins can disrupt intracellular protein homeostasis networks, thereby inducing various diseases [13]

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In particular, core symptoms (extenuating fatigue, cognitive problems, sleep disorders and pain) not only strengthen but often exacerbate each other, leading to isolation, depression, and sometimes even to a state that looks like PTSD