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[23] [24] Antibiotics can disrupt gut flora and occasionally lead to Clostridioides difficile infection

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In a separate study in 2023, Hu et al., 2023 demonstrated that CDGSH iron-sulfur domain 2 (CISD2) was upregulated and activated the Nrf2/HO-1 signaling pathway in both the MCAO mouse model and the OGD/R HT22 cell model, mimicking in vivo and ex vivo conditions of cerebral ischemia and reperfusion