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HFD-induced obese mice increased AF vulnerability and exhibited apparent atrial structural remodeling, including left atrial dilation, cardiomyocyte hypertrophy, connexin-43 remodeling and fibrosis

The evaluation of these metabolites and ratios uncovered biologically plausible biomarkers that expand upon the biochemical processes associated with the pathophysiology of autism

Furthermore, GSEA of all DEGs confirmed enrichment of pathways involving these 16 genes, including adaptive immune system terms, with directionality consistent with the primary pre/post-treatment comparison (Supplementary Fig

Importantly, proponents of this model argue against the simplistic approach of the carbohydrate-insulin-model neglecting that several variables in the food environment influence energy intake and energy partitioning