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This GPX1 polymorphism might confer a greater susceptibility to Keshan disease in carriers with low selenium nutritional status (53)

But this also means increasing intake of other key antioxidants like alpha-lipoid acid (ALA) to reduce oxidative stress and thus reduce demand for GSH

doi: 10.1126/science.165.3892.513 13 TakahashiYKipnisDMDaughadayWH

Ophiopogonin D improves osteointegration of titanium alloy implants under diabetic conditions by inhibition of ROS overproduction via Wnt/-catenin signaling pathway