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The exact mechanisms of most of the various forms of adult hemochromatosis, which make up most of the genetic iron overload disorders, remain unsolved

PGC-1 binds to peroxisome proliferator-activated receptors (PPARs), which act on dystrophic muscular systems, resulting in a reduced ability of mitochondria to oxidatively phosphorylate, and an increased production of ROS (41)

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Pretreatment with lactoferrin-CAY10603-loaded PLGA nanoparticles significantly reduced ROS levels by ~3.0-fold, indicating strong antioxidant activity