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The difference is that the topical claim has supporting human cosmetic studies behind it, while the injectable skin claim has mechanism plus animal data and nothing more

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Appl Physiol Nutr Metab 44(3):271281

These results also suggested that introduction of larger portions of the human Ig loci containing greater numbers of V genes, additional regulatory elements, and human Ig constant regions might recapitulate substantially the full repertoire that is characteristic of the human humoral response to infection and immunization