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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Wu J, Rowart P, Jouret F, Gassaway BM, Rajendran V, Rinehart J, Caplan MJ

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A reversed-U dose-response, where less works better than more, is the opposite of the more is stronger instinct a vial of research chemical sells on, and it is exactly the kind of inconvenient texture that only shows up when a compound is actually put through controlled trials

By exogenously applying Pal-KTTKS at low concentration to fibroblasts, the observed effect is paradoxically inverse: stimulation of type I and III collagen production and fibronectin