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Usually, these aggregates are intracellular but sometimes, as in the case of Alzheimer disease (AD), amyloid- also appears extracellularly and the intraneuronal tau aggregates persist in the extracellular space after the neuron dies 1

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81 Pimpinella anisum (Anise) and Illicium verum (Star anise) are other well-known carminatives traditionally consumed as teas to relieve indigestion, promote digestion, and reduce gas formation

Further mechanistic studies indicate that crocin exerts these effects through Nrf2 activation, offering a multitargeted approach to ameliorate secondary brain injury (198)