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Methods: Fresh frozen plasma from 157 patients with biopsy proven NAFLD were used to prepare VLDL using ultracentrifugation

doi:10.1016/j.ijbiomac.2019.06.104 135

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3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGCR) is a rate-limiting enzyme in the cholesterol biosynthesis pathway that converts HMG-CoA to mevalonate, which is overexpressed in several cancer types, including colorectal and liver cancer [233, 234]