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350 However, the protective effect of high-fiber diet may be reversed if there exists colonization of Prevotella copri , which leads to the overproduction of organic acids, including fumarate and succinate, during the digestion of complex fibers and the promotion of proinflammatory responses in macrophages, exacerbating arthritis in an RA model

Notably, STING-based immunotherapy was most effective when combined with anti-VEGFR2 and/or ICIs (either anti-PD-1 or anti-CTLA-4), leading to the complete regression of tumors that are resistant to either anti-angiogenic monotherapy or ICI monotherapy

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J Phys Chem C

The gut microbiome in Alzheimer's disease: what we know and what remains to be explored