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doi: 10.1016/j.yjmcc.2022.04.011 181 VergsBAboyansVAngoulvantDBoutouyriePCariouBHyafilFet al

This could be due to better muscle signaling or reduced inflammatory cytokines , though more research is needed

It enhances repair processes by promoting angiogenesis (partly through VEGF upregulation), reducing inflammation, and mobilizing progenitor cells

In the context of constitutive HIF-2 stabilization 75 or a defective mitochondrial electron transport chain 76 , glutamine-derived -KG is reductively carboxylated through the consumption of NADPH by IDH2 to generate citrate