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(2012), 9cRA was repeatedly administered through the intra-nasal route as intracerebral delivery is not feasible for repeated drug administration and may require chronic cannulation, whereas small molecules bypass the bloodbrain barrier and reach brain parenchyma non-invasively if delivered via the intranasal route

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It comes in green, white, and purple varieties, and can be enjoyed raw, cooked, or pickled

Collectively, these non-clinical data demonstrated a compelling pharmacological profile and an acceptable safety margin, thereby justifying progression to first-in-human studies and informing the initial dose-escalation schemes