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4 Potential role of mitochondrial dysfunction in RA-related immune-inflammation 4.1 Mitochondrial dysfunction affects immune-inflammatory pathways in RA 4.1.1 Nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 inflammasome pathway Nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) is an intracellular receptor that senses foreign pathogens and endogenous danger signals, which assembles with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and Caspase-1 to form polymeric proteins known as NLRP3 inflammasomes

Another known mechanism of tamoxifen resistance and sensitivity involves hyper and hypomethylation of estrogen response enhancers and methylation of histones enhancing transcription of ER target genes [154,155]

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The tripeptide comes in two forms oxidized and reduced

Mitochondria serve as a central hub, which plays a vital role in linking the above-mentioned key factors