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Imbalance in mitochondrial fission and fusion is a key trigger for Parkinsons disease, and defects in mitochondrial dynamics limit mitochondrial movement, leading to a reduction in ATP, excessive oxidative stress, and mtDNA deficiency, which ultimately leads to cell death (Wu et al., 2017), with a substantial body of evidence demonstrating the involvement of -Syn, DJ-1, LRRK2, PINK1, and Parkin in the regulation of mitochondrial dynamics and homeostasis through the Drp1 pathway (ODonnell et al., 2014

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The Growth Hormone Signaling Story Growth hormone is one of the clearest illustrations of this principle