elegans glutathione cytosolic mitochondrial GTP metabolism controls reproductive aging in C. UPR mt signaling pathway in

They have found that patients with FMS generally complain of decreased ability to concentrate, short-term memory difficulties, and problems with performing multiple tasks at one time

Pizzimenti 2015)

PMID: 38157568

Treatment of B6 mice with the GLS1 inhibitor BPTES significantly reduced histological scores in the spinal cord of affected animals, lowered the number of CD4 + T cells, IL-17A and IFN-producing CD4 + T cells in the spinal cord, substantially decreased clinical scores and weight loss, and ameliorated experimental autoimmune encephalomyelitis ( + CD4 - CD8 - cells), the urinary albumin/creatinine ratio, glomerular nephropathy score, and T-cell infiltration with IL-17A in the kidneys, relieving the EAE disease activity ( + T cells by inhibiting GLS1, glycolysis, and CD4 + T-cell differentiation in vitro by reducing the level of HIF1 protein, a key metabolic sensor in Th17 cells ( Table 1 )

Should two infusions be indicated, these are carried out two weeks apart