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Endogenous purines originate from nucleic acid breakdown of damaged/apoptotic cells, along with adenine and guanine degradation, whereas exogenous purines are primarily derived from dietary sources, including fructose-rich beverages and purine-rich foods (e.g., meat and seafood) (Weaver, 2019)

In contrast, in other cell types, it is found only in trace amounts

Neuroscience 506 , 2937 (2022)

Stability in aqueous nasal spray form is a real and under-discussed problem: no published stability data exist for commercial nasal formulations of BPC-157