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GRK2 knock-down reverses these gains (Xu X

The gels were imaged in gel-doc and quantified using ImageJ

For instance, accumulated succinate acts as a competitive inhibitor of -KGdependent dioxygenases, including the ten-eleven translocation (TET) family of DNA demethylases and Jumonji C domain-containing (JMJD) family histone demethylases, thereby promoting global DNA hypermethylation and transcriptional silencing [51]