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19), V4 (Fig

The main feature of diabetes is persistent hyperglycemia, which over time will cause endocrine and metabolic disorders in patients with diabetes and lead to complications of diabetes, which is the final outcome of diabetes and the main cause of great pain and economic loss to patients, and has become one of the most serious global public health problems (Li et al., 2022

We found that wild-type (WT) ACTL6A and the DNBL, CC, and NBC ACTL6A mutants reversed the inhibition of cell proliferation and the reduced GCLC protein expression induced by knocking down ACTL6A expression, but the ACTL6A HR-deleted mutant did not show this restorative effect (Fig